There are plenty of main quests in Diablo 4. Therefore, we've created an overview of all the main tasks in the action role-playing game, sorted by acts.
In this article, you will learn:
What main quests are available in Diablo 4.
What you need to do for each of these tasks.
In Diablo 4, the Main Quests are Spread Across 5 Regions
Since June 2nd, Diablo 4 has officially welcomed you to the realms of hell. At least if you've received early access from a Deluxe or Ultimate Edition. Otherwise, from June 6th onward, it's your tough job to defeat the formidable demoness Lilith.
On your way to your goal, you'll have to battle through a series of main quests that take place in five large game areas. To find out exactly what tasks await you and what you need to do within their framework, refer to the following overview.
Find many more guides to Diablo 4 in our comprehensive Guide Overview!
All Main Quests in Prologue: Wandering
Dusk on the Mountain
Seek shelter in a nearby town.
Talk to Oswen.
Follow Vani.
Talk to Vani.
Darkness Within
Enter the ruins of Frost Howl.
Search the depths of the Ruins of Frost Howl.
Examine the decapitated priest.
Kill X'fal.
A Hero's Return
Return to Nevesk.
Speak with Vani.
A Hero's Reward
Kill the mad villagers.
Talk to Iosef.
Loot the chapel key from Vani's corpse.
Prayers for Salvation
Unlock the chapel door.
Enter the chapel.
Examine the bloody flowers.
Talk to Iosef.
In Search of Answers
Find the hermit's hut.
Search the hut.
Right of Passage
Accompany Lorath to Kovashad.
Talk to Lorath.
Accompany Lorath to Kovashad.
Speak with Lorath.
Burn your sin.
Talk to the guard.
Missing Pieces
Meet Lorath in Kovashad.
Talk to Lorath.
Talk to the merchant.
Buy Lorath's polearm.
Take the strange amulet.
Bring the items to Lorath.
All main quests in Shattered Peaks
All Main Quests in Act I: A Cold and Iron Faith (Fractured Peaks)
III Tidings
Travel to the Cathedral of Light.
Enter the Cathedral of Light.
Speak with Mother Superior Prava.
Take Vigo's report.
Tarnished Luster
Travel to Yelesna.
Enter the Knights' Garrison.
Speak with Captain Ankers
The Knight and the Magpie
Visit the mining camp at Pine Hill.
Talk to Vigo.
Follow Vigo to the ore miner.
Kill the ghouls.
Go with Vigo to the locked gate.
Enter the old mine.
Undertaking
Follow Lilith and Vhenard.
Examine the door.
Follow Lilith and Vhenard with Vigo and Neyrelle.
Use the opening to escape from the mine.
Below
Talk to Vigo in the path of the firstborn.
Talk to Neyrelle.
Take Vigo and Neyrelle down into the caves.
Get the ore conveyor working.
In Her Wake
Talk to Vigo.
Open the gate of Kasama.
Talk to Grendan.
Search for Lilith and Vhenard with Neyrelle.
Examine Lilith's blood flowers.
Open the ancient gate.
Penetrate deeper into Kasama.
Open the gate of the cradle.
Storming the Gates
Enter the cradle.
Follow Lilith and Vhenard with Neyrelle.
Examine Lilith's blood blossoms.
Open the ancient gate.
Follow Lilith and Vhenard with Neyrelle.
Kill Roshaka.
Examine Lilith's blood flowers.
Open the ancient gate.
Follow Lilith and Vhenard with Neyrelle.
Talk to Neyrelle.
Protect Neyrelle while she opens the entrance.
Open the ancient gate.
Follow Lilith and Vhenard to the mourning shore.
The Cost of Knowledge
Search for Vhenard and Lilith with Neyrelle.
Speak with Neyrelle.
Kill the demonic servants of Vhenard.
Speak with Neyrelle.
Light's Guidance
Speak with Mother Superior Prava in the Cathedral of Light.
Travel to the Cathedral of Light.
Look for Mother Superior Prava.
Speak with Iosef.
Kor Valar
Talk to Mother Superior Prava in Kor Valar.
Travel to Kor Valar.
Search for Mother Superior Prava.
Talk to Vigo.
Speak with Mother Superior Prava.
Pilgrimage
Complete the pilgrimage to the Shrine of Penance.
Talk to Vigo.
Read from the tablet at the Altar of Purity.
Bring the idol of the faithful to the altar of martyrdom.
Read from the tablet at the Altar of Martyrdom.
Bring the idol of the faithful to the altar of salvation.
Read from the tablet at the altar of salvation.
Bring the idol of the faithful to the altar of the Anointed Ascension.
Read from the tablet at the altar of the Anointed Ascension.
Bring the Idol of the Faithful to the Shrine of Atonement.
Speak with Vigo.
Light's Judgment
Enter the alabaster monastery.
Climb the steps of the Hall of Ascension.
Pass through the Portal of Paternal Splendor to submit to Inarius.
Light's Protection
Speak with Mother Superior Prava in Kor Valar.
Return to Mother Superior Prava.
Speak with Mother Superior Prava.
Follow Mother Superior Prava.
Speak with Mother Superior Prava.
Wayward
Search for Neyrelle in the Mistral Forest.
Search for Neyrelle.
Shroud of the Horadrim
Enter the Darkened Grove.
Search for Neyrelle.
Pass through the Fiery Portal.
Follow the Bloody Wolf.
Talk to the Bloody Wolf.
Open the Living Gate.
Continue the journey with the Bloody Wolf.
Talk to the Bloody Wolf.
Use the Fiery Portal to return to the Darkened Grove.
Look for Neyrelle in the Darkened Grove.
Speak with Neyrelle.
Find the way to the Horadric Vault.
Examine the three-faced statue.
Fledgling Scholar
Travel to the Horadric Vault.
Enter the Horadric Vault.
Speak with Neyrelle.
Follow Neyrelle.
Look for an entrance to the main chamber.
Bring the Hodrarian book to Neyrelle.
Examine the door to the Horadric Vault with Neyrelle.
Explore the Horadric Vault.
Follow Neyrelle.
Talk to Neyrelle.
Look for clues on how to cross the Schwarten See.
Kill Tchort.
Examine the spellbook.
Bring the pulsating spellbook to Neyrelle.
Crossing Over
Talk to Neyrelle in the path of the firstborn.
Go with Neyrelle to the Black Lake.
Speak with Neyrelle.
Speak with Neyrelle.
Descent
Enter the necropolis of the firstborn.
Follow Lilith.
Destroy the tumors of hate blocking the way (3)
Kill the last tumor of hate to unblock the exit.
Follow Lilith.
Kill Lilith's lament.
Talk to the Knight of Remorse.
Follow Lilith through the Necropolis of the Firstborn.
Examine Lilith's blood flowers.
Light's Resolve
Speak with Neyrelle.
Diablo 4: All main quests in Scosglen
All Main Quests in Act II: The Knife Turns Again (Scosglen)
An Unforseen Visit
Find Donan at the bastion of Eldhaime.
Talk to the guard commander.
Talk to the guard.
Enter the bastion.
Find Donan.
Dark Omens
Investigate the disturbance in the Firebreak Estate.
Talk to the servant Wilfred.
Enter Donan's study.
Examine the blood flowers in Donan's study.
Investigate the riot.
Defeat the attacking goat people.
Talk to Donan.
Encroaching Shadows
Search near Braestaig for clues about Lilith.
Talk to Chief Asgail.
Talk to Yorin.
Find the entrance to the Mounds of Tears with Yorin.
Talk to Yorin.
Protect Yorin and defeat the attacking spirits.
Exhumation of the Forgotten
Enter the Mounds of Tears.
Find the way through the Mounds of Tears with Yorin.
Talk to Yorin.
Help Yorin open the rune-lined passage.
Find and place the missing protection stone in the Rune Adorned Menhir.
Find the way through the Mounds of Tears with Yorin.
Talk to Yorin.
Defeat the vengeful wildwood.
Find the way through the Mounds of Tears with Yorin.
Talk to Yorin.
Find the exit from the Hills of Tears.
Enter the Ancestral Heights.
Harrowed Lament
Find Airidah.
Investigate the disturbance.
Talk to Arlo.
Find and destroy the remains of the resurrected.
Return to Yorin.
Talk to Arlo.
Apex of Misery
Find Airidah on solitude.
Destroy the remains of the resurrected.
Find Airidah on Solitude.
Talk to Airidah.
Defeat Airidah.
Talk to Airidah.
Parting Embers
Speak with Yorin in Braestaig.
Ferral Nature
Ask the knights in Tirmair about Lilith.
Search for Nafain at the Boglann stone circle.
Examine the rune message on the stone.
The Beast Within
Join Nafain's wolf.
Follow Nafain's Wolf.
Join Nafain's wolf in the Heart of the Bog.
Find Nafain in the Heart of the Bog.
Talk to Nafain.
The Path of Rage
Follow the River of Corruption into the untamed thicket.
Destroy the unnatural growths that maintain the blockade at the untamed thicket.
Destroys the desecrated plug blocking the entrance to the untamed thicket.
Fangs of Corruption
Enter the untamed thicket.
Find out what lies at the end of the corruption.
Find a way to stop the birth of the Amalgam of Wrath.
Stemming the Flow
Return to Nafain.
Buried Secrets
Returns to the bastion of Eldhaime.
Return to Donan.
Search the bastion of Eldhaime for survivors.
Talk to Commander Antje.
In Ruins
Enter the ruins of Eldhaime.
Find a way to the Great Hall.
Find Donan in the Great Hall.
Talk to Donan.
Enter the barracks of Eldhaime.
Entombed Legacy
Go with Donan through the barracks of Eldhaime.
Go with Donan to the passageway.
Accompany Donan to Astaroth's tomb.
Go with Donan to the grave.
Examine the blood flowers.
Talk with Donan.
Shadows over Cerrigar
Join Donan in Cerrigar.
Enter Lower Cerrigar.
As the World Burns
Defeat Astaroth.
Talk to Donan.
Talk to the guard at the gate.
Diablo 4: All main quests in the Dry Steppes
All Main Quests in Act III: The Creation of Monsters (Dry Steppes)
The Spreading Darkness
Meet Lorath in Ked Bardu.
Look for Lorath in Ked Bardu.
Talk to Daruuk.
Wake Lorath from his slumber.
Talk to Teckrin.
Return to bring Lorath up to speed.
Whittling Sanity
Meet Lorath in Abahru Gorge.
Speak with Lorath in Abahru Gulch.
Search for Elias with Lorath in Abahru Gorge.
Defeat the demons coming out of the gate to hell.
Investigate the house.
Help Lorath look for clues in the farmhouse.
Talk to Lorath.
Find Genbar.
Talk to Genbar.
Defeat Genbar the shrine keeper.
Talk to Lorath.
Suffering Disquiet
Enter the halls of Orbei Monastery and search for the abbot.
Search for the abbot of the monastery.
Search the dead for a key.
Place the crusader skull on the pedestal.
Search for the abbot of the monastery.
Talk to the confused monk.
Repel the vengeful spirits.
Look for the abbot of the monastery.
Find the words of the secret litanies to enter the inner monastery.
Talk to the Abbot of Orbei.
Kill the Eidolon of Orbei in the Monastery of Orbei.
A Moment to Collect
Talk to Lorath in Ked Bardu.
Accompany Lorath to the autopsy.
Brought Low
Meet Lorath in Guulrahn.
Meet Lorath at the hidden vantage point.
The City of Blood and Dust
Enter Guulrahn and search for Oyuun.
Find the marketplace.
Search for Oyuun in the marketplace.
Talk to the villagers.
Find the prison.
Find a way into the Guulrahn prison.
Look for Oyuun in the prison.
Kill Akil, the jailer of the weak.
Take the prison keys.
Open Oyuun's cell.
Talk to Oyuun.
Find the secret way with Oyuun.
Destroy the weak wall.
Find the exit and escape from the prison with Oyuun.
Small Blessings
Talk to Oyuun.
Accompany Oyuun to Zolaya.
Speak with Oyuun.
Speak with Lorath.
Whispers from the Past
Talk to Lorath at the entrance of the slaughter pit.
Enter the slaughter pit.
Find the entrance to the old escape tunnel with Lorath.
Talk to Lorath.
Discover a way into the palace.
Listen secretly through the wall.
Enter the interior of the palace.
Search for Elias in the tyrant's court.
Kill the Mother's Judgment in the Tyrant's Court.
Examine the sign of sealing.
Enter Elias' sanctuary with Lorath.
Look for information about Elias' ritual.
Discuss your findings with Lorath.
Speak with Lorath outside.
Through the Dark Glass
Find a way into the Temple of the Great Evils.
Speak with Lorath at Mount Civo.
Take Lorath to Baal's shrine.
Receive the blessing of destruction.
Take Lorath to Diablo's shrine.
Receive the blessing of terror.
Take Lorath to Mephisto's shrine.
Speak with Lorath.
Receive the Blessing of Hate.
Pass through the Fiery Portal.
Speak with the bloody wolf.
Break through the barbarian fortification.
Kill Gorm.
Speak with Mephisto's Herald.
Leave the vision of Sescheron.
Talk to Lorath.
Descend into Flame
Enter the Temple of the Great Evils with Lorath.
Find the ritual site with Lorath.
Kill Malach.
Find the ritual site with Lorath.
Talk to Lorath.
Kill the tyrant king Brol.
Loose Threads
Talk to the mysterious woman.
Talk to Lorath.
Diablo 4: All main quests in Kehjistan
All Main Quests in Act III: The Creation of Monsters (Kehjistan)
Oasis of Memories
Meet with Lorath and Taissa in Tarsarak.
Talk to Lorath.
Look for a guide in Tarsarak.
Meet with Lorath.
Travel to the riverbank of Argentek.
Find the entrance to the drug den.
Kill the bar patrons.
Enter the back room and look for the old man.
Talk to the strange old man.
Flesh from Bone
Meet Lorath and Meshif at the Abandoned Chapel.
Talk to Lorath.
Talk to Meshif.
Meet Meshif outside the storm.
Check on Meshif.
Follow Meshif through the sandstorm.
Take cover with Meshif.
Let the strong wind pass.
Talk to Meshif to continue the journey.
Follow Meshif through the sandstorm.
Take cover with Meshif.
Let the strong wind pass.
Talk to Meshif to continue the journey.
Follow Meshif through the sandstorm.
Protect Meshif and Isabella.
Take cover with Meshif.
Let the strong wind pass by.
Talk to Meshif to continue the journey.
Follow Meshif through the sandstorm.
Beneath the mask
Talk to Meshif.
Find the entrance to the Sublime Terrace with Lorath.
Speak with the nobleman.
Behind the Veil
Enter the Sublime Terrace.
Find Elias on the Sublime Terrace.
Talk to the nobleman.
Bring Lorath to Elias.
Confront Elias with Lorath.
Kill Elias.
Examine the blood flowers.
Kill Elias.
Find the Hidden Eye.
Kill Elias.
Talk to Lorath.
Escape from the window.
Exhumed Relics
Talk to Meshif.
Meet with Lorath in the Abandoned Chapel.
All Main Quests in Act IV: A Gathering Storm
Prying the Eye
Talk to Taissa.
Bring the Hidden Eye to the pedestal.
Look into the Hidden Eye.
A Master's Touch
Meet Donan in the Cathedral of Light.
Speak with the elder Donan.
Lost Arts
Enter the Horadric Vault in Mistral Forest.
Speak with Donan.
Open the door to the study.
Speak with Neyrelle.
Follow Donan.
Take Donan to his desk.
Protect Donan.
Take Donan to his desk.
Get rid of the spiders.
Take Donan to his desk.
Talk to Donan.
Return to the study.
Talk to Neyrelle.
A Meeting of the Minds
Meet your allies in the Abandoned Chapel.
Talk to Neyrelle.
Look for Taissa.
Speak with Neyrelle.
Anguish Incarnate
Defeat Andariel.
Eye of the Storm
Check on your companions.
Speak with Lorath.
Diablo 4: All main quests in Hawezar
All Main Quests in Act V: Sold Fates (Hawezar)
The Path Divided
Meet your allies in Zarbinzet.
Talk to Taissa.
Talk to Donan.
Secrets of the Zakarum
Meet with Donan.
Talk to Donan.
Find a way into the Zakarum bastion.
Open the portcullis.
Talk to Donan.
Follow Donan.
Talk to Donan.
Entombed Hate
Enter the Rotten Undercrypt.
Search the Rotten Undercrypt.
Kill the Urpaladin and his guards.
Break open the reinforced door.
Accompany Donan to the Black Crypt of Sankekur.
Talk to Donan.
Protect Donan.
Destroy the manifestation of hate.
Speak with Donan.
Swamp Hospitality
Search for Donan in Wejinhani.
Speak with Donan.
Accompany Donan to the tower.
Speak with Taissa.
Witch of the Wastes
Search for Valtha in the Wasteland.
Search Valtha's hut for purified mercury.
Talk to Valtha.
Kill Valtha.
Take the purified mercury.
Bring the purified mercury to Donan.
Put the vial with the purified mercury on the table.
Talk to Taissa.
Encumbered Mind
Mix the mercury with other liquids.
Turn the wheel three times.
Grind the sulfur.
Observe Donan.
Follows Taissa.
The Cage of Grief
Accompany your allies to the Starving Swamp.
Take Taissa and Donan to the ritual site.
Speak with Taissa.
Collect yellow lotus.
Collect maggot queen's secretion.
Kill maggots to summon the Maggot Queen.
Take the swamp secretion.
Return to the ritual site.
Put the maggot queen secretion into the boiling pot.
Put the yellow lotus into the boiling pot.
Talk to Taissa in the Starving Swamp.
Light the fire bowls at the ritual site.
Talk to Taissa.
Pass through the Fiery Portal.
Follow the Herald of Hatred.
Speak with the Herald of Hate.
Follow the Herald of Hate.
Speak with the Herald of Hate.
Exit the Fiery Portal.
One Step Forward
Talk to Taissa.
Talk to Donan.
Mix the mercury with other liquids.
Turn the wheel twice.
Grind the sulfur.
Talk to Donan.
Tainted Flesh
Find Lorath and Neyrelle.
Talk to Lorath.
Search for Timue with your allies.
Enter Timue's hut.
Speak with Timue.
Wrack & Ruin
Find the city of Yngovani.
Find the temple in Yngovani.
Examine the engraved stone door.
Find the left eye.
Talk to the survivor.
Collect the left eye.
Insert the left eye.
Find the right eye.
Collect the right eye.
Use the right eye.
Cold Blood
Search the serpent's den.
Open the incense box.
Kill Mohlon, the snake queen, in the snake chasm.
Take the mystical incense.
Take the incense to Lorath in Yngovani.
Judgment of the Swamp
Catch up with Lorath and Neyrelle.
Talk to Neyrelle.
Follow Lorath.
Kill the Nangari.
Light the incense.
The Serpentine Path
Talk to Neyrelle.
Follow the snake with your allies.
Survive the ambush.
Reach Neyrelle.
Escape the sinking debris.
Dirge of the Mire
Talk to Neyrelle.
Follow the snake with your allies.
Find a way through the swamp.
Follow the snake with your allies.
Destroy the dead trees.
Follow your allies into the voiceless grove.
Destroy the wailing soul.
Kill all the enemies.
Follow Neyrelle.
The Slow, Beating heart
Talk to Neyrelle.
Follow your allies across the snake.
Follow your allies across the snake.
Speak with the Whispering Tree.
Speak with Lorath.
A Cold and Lifeless Shore
Talk to Lorath and Neyrelle.
Talk to Lorath.
Search the wrecks with your allies.
Talk to Neyrelle.
Picking Through the Bones
Search beyond the wrecks for the coffin with your allies.
Break open the soaked door.
Talk to Neyrelle.
Get to the coffin.
Examine the coffin.
Beneath the Wine-Dark Sea
Uncover Elias' secret in the temple.
Expel the remaining echoes of Elias.
Search for the secret behind Elias' ritual.
Gather Elias' mummified finger.
Escapes from the rising water.
Fragments of Mortality
Talk to Lorath.
Burn Elias' mummified finger.
Talk to Neyrelle.
On the Precipice
Join your allies in the Zakarum Bastion.
Speak with Donan.
Follow Donan to the Black Crypt of Sankekur.
Talk to Donan.
Follow Taissa.
Kill Elias.
Catch up with Taissa.
Talk to Taissa.
Knee-Deep in Faith
Follow Elias with Taissa through the Plague Bog.
Talk to Lorath.
Talk to Taissa.
A Chorus of Voices
Reach Lorath at the Whispering Tree.
Speak with Lorath.
All Main Quests in Act VI: Dance of the Creators
Evil Stirs in Kehjistan
Meet with the Horadrim in Tarsarak.
Meet with the Horadrim at the Thirsty Wanderer Inn in Tarsarak.
Speak with Neyrelle.
The Jewel of the East
Join your allies in the search for Lilith in Caldeum.
Speak with the Horadrim in the Caldeum Bazaar.
Search for Lilith.
Follow Inarius.
Find Inarius with your allies.
Open the gate.
Talk to Lorath.
Open the gate to the alley.
Look for the gates of hell.
Defeat the demons attacking Prava.
Talk to Prava.
The Scouring of Caldeum
Tell Prava that you are ready.
Escort your allies through Caldeum.
Kill demons attacking from above.
Investigate the big roof.
Kill the commander of the demons.
Join your allies.
Escort your allies through Caldeum.
Talk to Lorath.
Open the gate.
The Walls Shake
Find a way into the Imperial Palace.
Defeat Duriel.
Turning the Tide
Search for your allies in the Imperial Palace.
Follow Neyrelle to the other Horadrim.
Speak with Lorath.
Descend to the Gates of Hell with your allies.
Examine the Blood Blossoms.
Speak with Neyrelle.
Essence of Hatred
Join your Horadrim allies in the Burning Hells.
Search for Inarius' army with your allies.
Defend your allies from the attackers.
Kill the remaining demons.
Explore the Burning Overpass.
Move the body of Mother Superior Prava.
Talk to Mother Superior Prava.
In Desolation's Wake
Speak with Donan.
Escort your allies through the Realm of Hate.
Defeat the attackers in the Burning Hells.
Escort your allies through the Realm of Hate.
Speak with Lorath.
Kill Karum, the Hound of Hate.
Lead your allies through the Twisted Path.
Defeat the demons.
Follow Lorath.
Speak with Lorath.
Defeat Ashava.
Light Extinguished
Speak with Lorath.
Follow your allies to the Tower of Agony.
Investigate the Tower of Agony.
Investigate the Blood Blossoms.
Talk to Neyrelle.
Follow Lorath.
Use the Hidden Eye.
Defeat the enemies.
Talk to Donan.
Talk to Lorath.
Follow your allies to the Tower of Agony.
Examine the Tower of Agony.
Use the Hidden Eye.
The Blind Eye
Explore the nightmare.
Talk to the priest.
Examine Rathma's corpse.
Explore the nightmare.
Examine Lilith's altar.
Defend yourself against Lilith's attack.
Pass through the fiery portal.
Examine the cave.
Investigate the bonfire.
Find the way out.
Defeat the nightmares.
Find the way out.
Use the Hidden Eye.
What Lies Ahead
Talk to Neyrelle.
Find Neyrelle.
Talk to Neyrelle in the Burning Hells.
Pass through the Fiery Portal.
Find Mephisto in the Cathedral of Hate.
Bring Neyrelle to Mephisto.
Talk to Neyrelle in the Cathedral of Hate.
Defeat Lilith.
Talk to Lorath.
All Main Quests in Epilogue
Promises
Meet Neyrelle in the chapel.
Talk to Lorath.
Go outside with Lorath.
Talk to Iosef.
Defeat the Knights of Remorse.
Talk to Lorath.
A Heavy Burden
Search for Neyrelle in the Horadric Vault.
Examine the rune letter.
Legacy of the Horadrim
Meet Lorath at the Firebreak Manor.
Talk to Lorath.
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